Dr. Larrye Ellis Loss is a seasoned pharmaceutical executive, consultant, and board advisor with over 40 years of experience driving innovation and strategy across the global life sciences landscape. With a proven track record in drug development, clinical research, medical affairs, and strategic program management, Dr. Loss has held numerous senior leadership roles in both public and private organizations, including a distinguished tenure at AstraZeneca. Today, as Principal of Larrye E. Loss, LLC, he advises small and mid-sized pharmaceutical companies on clinical operations and medical strategy, providing critical guidance that enhances efficiency, compliance, and scientific rigor in development programs.
Larrye’s career reflects a unique blend of scientific expertise, business acumen, and operational excellence. He has led or contributed to the clinical development and global launch of numerous successful pharmaceutical products, including landmark programs with New Drug Applications (NDAs) and Marketing Authorization Approvals (MAAs) across more than 90 countries. Throughout his leadership journey, he has developed and directed multi-billion-dollar global R&D programs, guided multidisciplinary teams, and overseen collaborations across regulatory, commercial, and payer landscapes. Notably, he has also contributed to several high-impact publications in JAMA and other peer-reviewed journals on cardiovascular outcomes, pharmacotherapy, and clinical trial design.
Complementing his corporate leadership, Larrye has an enduring commitment to education, mentorship, and volunteerism. He has served as an adjunct professor and lecturer at several leading pharmacy schools, training the next generation of PharmD candidates and clinical researchers. A passionate advocate for community service, Larrye holds active leadership roles with the American Red Cross—serving in disaster relief and workforce engagement capacities—and has spent decades in governance and committee roles for nonprofit organizations, including his congregation.
In addition to his contributions in healthcare and academia, Larrye is also known for his values-based leadership style. His personal and business unifying principles emphasize integrity, rational thinking, fairness, and a strong sense of justice. He approaches every challenge with a clear sense of purpose and a commitment to excellence—qualities that have earned him the respect of colleagues, mentees, and partners alike. These principles are not only the foundation of his personal life but also guide his professional approach to solving complex problems and empowering others.
Larrye is industry agnostic and brings a global perspective, having worked extensively in Europe, China, Japan, Korea, Australia, New Zealand, and the Americas. With a foundation in pharmacy, pharmacology, and business—holding degrees from the Philadelphia College of Pharmacy, Temple University, and an MBA from the University of Phoenix, along with a PMP certification from the Project Management Institute—he is uniquely equipped to connect the scientific, regulatory, and business dimensions of health innovation.
Driven by values of honesty, intellectual growth, and a commitment to excellence, Larrye seeks to share his accumulated knowledge through board service. His broad cross-functional expertise, international experience, and passion for guiding teams make him an invaluable resource for boards seeking thoughtful governance, operational insight, and leadership in health, science, or mission-driven enterprises.
Character: Larrye Loss is guided by integrity, fairness, and a deep commitment to ethical leadership, both personally and professionally.
Knowledge: With over four decades in global pharmaceutical development, he brings unparalleled expertise in clinical research, medical affairs, and regulatory strategy.
Strategic: Larrye has successfully led multi-billion-dollar programs and global initiatives, consistently aligning scientific innovation with business objectives.
Communication: He is a skilled communicator and mentor, known for fostering collaboration across cross-functional teams and engaging diverse stakeholders with clarity and purpose.
