Agile methodologies have emerged as a powerful catalyst for transformation within large organizations, especially in complex and rapidly evolving sectors like healthcare. Drawing from my experience at Sentara Health, this article explores how embracing agile practices can streamline operations, foster a culture of adaptability, and drive meaningful cost and efficiency gains. By shifting away from rigid project management frameworks toward iterative, cross-functional collaboration, we unlocked greater innovation and responsiveness across the organization. As the healthcare industry continues to face mounting pressures, the adoption and scaling of agile methodologies—supported by technology and a commitment to continuous learning—are proving essential for achieving long-term organizational agility and improved patient outcomes.